What's new for 2017?

CONTACT SEDIMENT TOXICITY AND GENOTOXICITY TESTS:

EBPI has developed and launched the contact sediment test for both detection of toxicity and genotoxicity.

The SediTox platform is based on the novel bacterial strains also used in the EBPI line of Toxi-ChromoTest, SOS-ChromoTest and the UMUChormoTest products as well as Vibrio fischeri bioluminescent bacteria.

The SediTox Kit employs a direct sediment exposure method to assess total responses from all soluble, insoluble, organic, inorganic, and volatile molecules in a given sample.

 seditment Toxicity Test Tree

BENEFITS OF THE SEDITOX

  • -   Rapid bacterial-based colorimetric (or bioluminescent) bioassay for acute toxicity or genotoxicity . 
  • -   The  assay will detect additive, synergistic and antagonistic effects in toxicant mixtures. 
  • -   Sensitive to a wide spectrum of toxic (genotoxic) substances. 
  • -   The EBPI Express SOS and UMU Strains can be utilized to detect genotoxic potential of metabilites. 
  • -   Detection of direct toxicity (genotoxicity) without the need for labour intensive extraction procedures.

 

Ames-Express Bacterial Strains:

 

ames Express P450EBPI is proud to officially announce the release of our NEW Ames bacterial strains, called the Ames-ExpressTM strains.  Ames-ExpressTM strains are constructed from normal Ames bacterial strains (TA100, TA98, TA1535, TA97a, TA1538), but have been engineered to also express either human P450 or GST-theta liver enzymes internally, which promotes bioactivation of xenobiotic molecules into DNA reactive species in the absence of an S9 mix.  

 

A few of the benefits of the Ames-Express strains include:

  • -   Short-lived, reactive metabolites are created within the bacterial cell in close proximity to target DNA.
  • -   Eliminates the need to incorporate S9 liver extract.
  • -   Improvements in sensitivity and selectivity compared to traditional Ames assays.
  • -   Response suppression from interactions with S9 lysate mix is eliminated.
  • -   The system expresses recombinant human proteins rather than rat liver extract, which improves extrapolation of mutagenicity data to human health endpoints.

 

Please visit, EBPI Toxicity Test/Ames Express for further information or download our Ames Express Handout here.

 

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